Science can...

…sustain and grow the success of AstraZeneca, help us to transform the future of healthcare, and the health of people, society and the planet.



Underpinning confidence in the future is our scientific leadership that continues to deliver life-changing and innovative medicines to patients.

Leif Johansson, Chair, AstraZeneca

Our R&D success and revenue increase in 2022 demonstrate that we are on track to deliver industry-leading revenue growth through 2025 and beyond, and have set AstraZeneca on a path to deliver at least 15 new medicines before the end of the decade.

Pascal Soriot, Chief Executive Officer, AstraZeneca


01

Our approach to R&D

Science, empowered by digital technologies, data and AI, can…
accelerate our understanding of disease and our ability to predict success. Increase engagement in the clinic and beyond.


We are using our distinctive scientific capabilities to deliver a pipeline of life-changing medicines. This includes reinforcing our continued focus on science and innovation, from discovery through development and life-cycle management, to further our productivity and outcomes.


Development pipeline overview


2022 was another exceptional year for our science, with our pipeline producing overwhelmingly positive news for patients. This included 72 regulatory events, either submissions or approvals for our medicines in major markets, including two NME first approvals. This performance is backed by a healthy pipeline of high potential medicines, with a total of 29 pipeline progression events, either NME Phase II starts or Phase III investment decisions, indicating our ability to deliver longer-term sustainable growth.




Phase I1


Oncology 26%

Cardiovascular, Renal & Metabolism 29%

Respiratory & Immunology 16%

Vaccine & Immune Therapies 0%

Rare Disease 19%

Other 10%
 

1 Includes NMEs and additional indications if the lead is not yet launched.



Phase II1


Oncology 41%

Cardiovascular, Renal & Metabolism 21%

Respiratory & Immunology 17%

Vaccine & Immune Therapies 0%

Rare Disease 14%

Other 7%
 

1 Includes NMEs and additional indications if the lead is not yet launched.



Late stage development1


Oncology 47%

Cardiovascular, Renal & Metabolism 11%

Respiratory & Immunology 18%

Vaccine & Immune Therapies 8%

Rare Disease 16%

Other 0%
 

1 Includes NMEs and additional indications if the lead is not yet launched.



Life-cycle management projects2

Oncology 72%

Cardiovascular, Renal & Metabolism 10%

Respiratory & Immunology 12%

Vaccine & Immune Therapies 0%

Rare Disease 6%

Other 0%
 

2 Only includes major LCM projects.



02

Our Therapy Area focus

Science can…
help people with chronic diseases live better, healthier lives. Redefine cancer care. Pioneer treatments for rare diseases.


We’re focussed on the areas where we can make the most meaningful difference to patients.



03

Our environmental commitment

Science can…
help us take bold action on climate change.


We recognise the connection between healthy people and a healthy planet. A significant impact of climate change is increasing levels of ill health, including a rise in chronic conditions such as heart disease, stroke, lung cancer and respiratory disease.



Near-term target:

98% reduction in Scope 1 and 2 GHG emissions by 2026 from 2015 baseline.

We are accelerating the delivery of net-zero healthcare and our progress towards net-zero. We were one of the first companies to have our net-zero targets across Scope 1, 2 and 3 verified under the Science Based Targets initiative Net-Zero Corporate Standard.


Achievements in 2022:

-59.3%

Reduction of Scope 1 and 2 GHG emissions from 2015 baseline year.
(2021: -58.6% reduction)



Near-term target:

Launching first next-generation respiratory inhalers with near-zero climate impact by 2025.

We follow a life-cycle approach that covers all stages of our products and our internal Product Sustainability Index ensures we understand their environmental impacts and prioritise improvement opportunities.


Achievements in 2022:

100%

Safe API discharges for AstraZeneca sites and 92% safe API discharges for globally managed first-tier supplier sites.



Near-term target:

Plant and steward more than 50 million trees by the end of 2025 through our AZ Forest global initiative.

We have AZ Forest activities in Australia, Indonesia, and the UK, in addition to two new projects announced in 2022 in Ghana and the US.


Achievements in 2022:

>10.5m

Trees planted by AZ Forest since 2020.



04

Our commitment to equitable access

Science can…
make healthcare systems more resilient. Increase access to healthcare for patients.



05

Our ways of working

Science can…
help us work inclusively and collaboratively across our company and with others. Supporting new talent and ideas.


We grow and prosper by recruiting, retaining and developing talented people. We do that by being a great place to work, encouraging and rewarding innovation, entrepreneurship and high performance. We also collaborate with others to access the best science, stimulate innovation and accelerate the delivery of new medicines.



06

Our performance

Science can...
sustain and grow the success of AstraZeneca.


Net cash flow from operating activities

$9.8bn 

Up 64% at actual rate of exchange to $9,808 million


Reported EPS*

$2.12

Increase in Reported EPS to $2.12
(2021: $0.08)
*Reported EPS is up 2,581% at actual rate of exchange to $2.12 (up 4,903% at CER).


Core EPS

$6.66 

Up 26% at actual rate of exchange to $6.66
(up 33% at CER)


• Used for remuneration of Executive Directors



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